MALDI imaging mass spectrometry of N-linked glycans on formalin-fixed paraffin-embedded murine kidney
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چکیده
منابع مشابه
MALDI imaging mass spectrometry of N-linked glycans on formalin-fixed paraffin-embedded murine kidney
Recent developments in spatial proteomics have paved the way for retrospective in situ mass spectrometry (MS) analyses of formalin-fixed paraffin-embedded clinical tissue samples. This type of analysis is commonly referred to as matrix-assisted laser desorption/ionization (MALDI) imaging. Recently, formalin-fixed paraffin-embedded MALDI imaging analyses were augmented to allow in situ analyses ...
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Aberrant glycosylation is associated with most of the diseases. Direct imaging and profiling of N-glycans on tissue sections can reveal tissue-specific and/or disease-associated N-glycans, which not only could serve as molecular signatures for diagnosis but also shed light on the functional roles of these biomolecules. Mass spectrometry imaging (MSI) is a powerful tool that has been used to cor...
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ژورنال
عنوان ژورنال: Analytical and Bioanalytical Chemistry
سال: 2014
ISSN: 1618-2642,1618-2650
DOI: 10.1007/s00216-014-8293-7